Rujukan Isositrat dehidrogenase

  1. ↑ PDB: 1CW7​; Cherbavaz DB, Lee ME, Stroud RM, Koshland DE (January 2000). "Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase". Journal of Molecular Biology. 295 (3): 377–385. doi:10.1006/jmbi.1999.3195. PMID 10623532.
  2. ↑ "Peroxisomal NADP-Dependent Isocitrate Dehydrogenase. Characterization and Activity Regulation during Natural Senescence". Plant Physiology. 121 (3): 921–928. November 1999. doi:10.1104/pp.121.3.921. PMC 59455. PMID 10557241.
  3. 1 2 3 4 5 6 PDB: 1LWD​; "Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism". The Journal of Biological Chemistry. 277 (45): 43454–43462. November 2002. doi:10.1074/jbc.M207306200. PMID 12207025.
  4. 1 2 "A highly specific monomeric isocitrate dehydrogenase from Corynebacterium glutamicum". Archives of Biochemistry and Biophysics. 383 (2): 238–245. November 2000. doi:10.1006/abbi.2000.2082. PMID 11185559.
  5. 1 2 "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary". Neuro-Oncology. 23 (8): 1231–1251. August 2021. doi:10.1093/neuonc/noab106. PMC 8328013 Check |pmc= value (bantuan). PMID 34185076. Unknown parameter |displayauthors= ignored (bantuan)
  6. ↑ "Structural, kinetic and chemical mechanism of isocitrate dehydrogenase-1 from Mycobacterium tuberculosis". Biochemistry. 52 (10): 1765–1775. March 2013. doi:10.1021/bi400037w. PMC 3706558. PMID 23409873.
  7. ↑ "Role of a peroxisomal NADP-specific isocitrate dehydrogenase in the metabolism of the riboflavin overproducer Ashbya gossypii". Journal of Molecular Catalysis B: Enzymatic. 10 (1–3): 335–343. 2000. doi:10.1016/S1381-1177(00)00135-1.
  8. ↑ "Comprehensive discovery of novel structured noncoding RNAs in 26 bacterial genomes". RNA Biology. 18 (12): 2417–2432. December 2021. doi:10.1080/15476286.2021.1917891. PMC 8632094 Check |pmc= value (bantuan). PMID 33970790. Unknown parameter |displayauthors= ignored (bantuan)
  9. 1 2 3 4 Begley TP, McMurry J (2005). The Organic Chemistry of Biological Pathways. Roberts and Co. Publishers. m/s. 189–190. ISBN 0-9747077-1-6.
  10. 1 2 3 4 Cox M, Nelson DR, Lehninger AL (2005). Lehninger Principles of Biochemistry. San Francisco: W.H. Freeman. m/s. 609–611. ISBN 0-7167-4339-6.
  11. 1 2 "Crystal structure of the monomeric isocitrate dehydrogenase in the presence of NADP+: insight into the cofactor recognition, catalysis, and evolution". The Journal of Biological Chemistry. 278 (38): 36897–36904. September 2003. doi:10.1074/jbc.M304091200. PMID 12855708.
  12. ↑ Garrett R, Grisham CM (2012). Biochemistry. Cengage Learning. m/s. 621. ISBN 978-1133106296.
  13. ↑ "Nondecarboxylating and decarboxylating isocitrate dehydrogenases: oxalosuccinate reductase as an ancestral form of isocitrate dehydrogenase". Journal of Bacteriology. 190 (6): 2050–2055. March 2008. doi:10.1128/JB.01799-07. PMC 2258884. PMID 18203822.
  14. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability". Journal of Molecular Biology. 372 (1): 130–149. September 2007. doi:10.1016/j.jmb.2007.06.040. PMID 17632124.
  15. ↑ "Monoclonal antibody specific for IDH1 R132H mutation". Acta Neuropathologica. 118 (5): 599–601. November 2009. doi:10.1007/s00401-009-0595-z. PMID 19798509.
  16. ↑ "Clinical development of IDH1 inhibitors for cancer therapy". Cancer Treatment Reviews. 103: 102334. February 2022. doi:10.1016/j.ctrv.2021.102334. PMID 34974243 Check |pmid= value (bantuan). Unknown parameter |displayauthors= ignored (bantuan)
  17. ↑ "Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas" (PDF). Acta Neuropathologica. 120 (6): 707–718. December 2010. doi:10.1007/s00401-010-0781-z. PMID 21088844. Unknown parameter |displayauthors= ignored (bantuan)
  18. ↑ "The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone". Neuro-Oncology. 16 (9): 1263–1273. September 2014. doi:10.1093/neuonc/nou005. PMC 4136888. PMID 24510240. Unknown parameter |displayauthors= ignored (bantuan)
  19. ↑ "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate". Cancer Cell. 17 (3): 225–234. March 2010. doi:10.1016/j.ccr.2010.01.020. PMC 2849316. PMID 20171147. Unknown parameter |displayauthors= ignored (bantuan)
  20. ↑ "WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation". Molecular Cell. 57 (4): 662–673. February 2015. doi:10.1016/j.molcel.2014.12.023. PMC 4336627. PMID 25601757. Unknown parameter |displayauthors= ignored (bantuan)
  21. ↑ "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate". Nature. 465 (7300): 966. June 2010. Bibcode:2010Natur.465..966D. doi:10.1038/nature09132. PMC 3766976. PMID 20559394. Unknown parameter |displayauthors= ignored (bantuan)
  22. ↑ "The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases". EMBO Reports. 12 (5): 463–469. May 2011. doi:10.1038/embor.2011.43. PMC 3090014. PMID 21460794. Unknown parameter |displayauthors= ignored (bantuan)
  23. ↑ "The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1846 (2): 326–341. December 2014. doi:10.1016/j.bbcan.2014.05.004. PMID 24880135.
  24. ↑ "Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2". Nature Genetics. 43 (12): 1262–1265. November 2011. doi:10.1038/ng.994. PMID 22057236. Unknown parameter |displayauthors= ignored (bantuan)
  25. ↑ "Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases". Nature Communications. 5: 3423. March 2014. Bibcode:2014NatCo...5.3423T. doi:10.1038/ncomms4423. PMC 3959194. PMID 24594748. Unknown parameter |displayauthors= ignored (bantuan)
  26. ↑ "Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation". Nature. 483 (7390): 484–488. February 2012. Bibcode:2012Natur.483..484K. doi:10.1038/nature10898. PMC 3656605. PMID 22343896. Unknown parameter |displayauthors= ignored (bantuan)
  27. ↑ "Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function". Science. 377 (6614): 1519–1529. September 2022. doi:10.1126/science.abj5104. PMC 9629749 Check |pmc= value (bantuan). PMID 36173860 Check |pmid= value (bantuan). Unknown parameter |displayauthors= ignored (bantuan)
1.1.1: NAD/NADP sebagai penerima
1.1.2: sitokrom sebagai penerima
1.1.3: oksigen sebagai penerima
1.1.4: disulfida sebagai penerima
1.1.5: kuinon/penerima serupa
1.1.99: penerima lain
Kitaran
Anaplerotik
menjadi asetil-KoA
menjadi asid α-ketoglutarik
menjadi suksinil-KoA
menjadi asid oksaloasetik
Mitokondria
rantaian pengangkutan elektron/
pemfosforilan oksidatif
Utama
Lain-lain
Protein mitokondrion
Membran luar
penguraian asid lemak
metabolisme triptofan
metabolisme
neurotransmiter monoamine
Ruang antara membran
Membran dalam
pemfosforilan oksidaan
metabolisme pirimidina
pengulangalikan mitokondrion
steroidogenesis
lain-lain
Matriks
kitaran asid sitrik
tindak balas anaplerotik
kitaran urea
metabolisme alkohol
Lain-lain/akan dikelaskan
DNA mitokondrion
Kompleks I
Kompleks III
Kompleks IV
ATP sintase
tRNA

Rujukan

WikiPedia: Isositrat dehidrogenase https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59455 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83280... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC37065... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86320... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22588... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41368... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28493... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43366... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC37669... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30900...